Rangers and St Johnstone go head to head this evening from 7.35pm, live on BBC 1 Scotland, with the winner joining St Mirren in the final of the CIS Cup.
Having seen both Pedro Mendes and Jerome Rothen depart, Rangers will also be without key players such as Kenny Miller, DaMarcus Beasley, Maurice Edu and Madjid Bougherra for what should be a difficult evening at Hampden.
Assistant manager Ally McCoist will take charge of first team affairs as is the norm in cup fixtures, as the Ibrox side attempt to continue their impressive record of reaching every domestic final since Walter Smith and McCoist returned.
Former Gers midfielder Derek McInnis will add new signing Mark Connolly to his St Johnstone squad whilst giving star striker Kenny Deuchar and Chris Millar until kick-off to pass fit.
Although the Saints have performed above expectations this season and are undefeated in their last two outings, Rangers have beaten the McDiarmid Park outfit both home and away already this term.
With Celtic falling ten points behind the Champions last night, Rangers will be full of confidence and should be good enough to progress here at 1/3 offered by Bet 365.
The Gers have been winning at half time and full time in both league fixtures between the sides this season and are offered at 10/11 to do the same again (Extrabet).
Spaniard Nacho Novo is well renowned for scoring important goals in a light blues shirt and after finding the net against St Johnstone in their last meeting, he can be picked up at 11/10 (Bet365) to repeat the feat.
